Extravascular injection may cause local tissue damage with subsequent necrosis; consequences of intra-arterial injection may vary from transient pain to gangrene of the limb. Any complaint of pain Per the limb warrants stopping the injection.
1. Under the influence and appreciably impaired for purposes of driving a motor vehicle or performing tasks requiring alertness and unimpaired judgment and reaction time.
Barbiturates appear to enhance the metabolism of exogenous corticosteroids probably through the induction of hepatic microsomal enzymes. Patients stabilized on corticosteroid therapy may require dosage adjustments if barbiturates are added to or withdrawn from their dosage regimen.
Per mezzo di a published study, administration of an anesthetic quota of ketamine for 24 hours on Gestation Day 122 increased neuronal apoptosis Sopra the developing brain of the fetus. Durante other published studies, administration of either isoflurane or propofol for 5 hours on Gestation Day 120 resulted in increased neuronal and oligodendrocyte apoptosis Per mezzo di the developing brain of the offspring.
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If phenobarbital and doxycycline are administered concurrently, the clinical response to doxycycline should be monitored closely.
Based on animal data, repeated or prolonged use of general anesthetics and sedation drugs, including pentobarbital, during the third trimester of pregnancy may result Durante adverse neurodevelopmental effects Sopra the fetus. (See Pediatric Use under Cautions and also see Advice to Patients.)
Possible enhanced metabolism of estrogenic and progestinic components; potential for decreased oral contraceptive effectiveness and increased risk of pregnancy with pentobarbital pretreatment or concurrent therapy
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Phenobarbital lowers the plasma levels of dicumarol (name previously used: bishydroxycoumarin) and causes a decrease in anticoagulant activity as measured by the prothrombin time. Barbiturates can induce hepatic microsomal enzymes resulting Durante increased metabolism and decreased more info anticoagulant response of oral anticoagulants (e.
Use with caution; should not be used Durante patients with marked hepatic impairment, including patients with premonitory signs of hepatic coma.
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